CRO Services

Drug discovery meets AI

At MatGen, we merge data science with computational chemistry and biology, bioinformatics, software development, and cheminformatics. Our experience spans various biotech and pharmaceutical collaborations, either as a close partner or an independent analysis service provider.

Scroll down for more details on the type of services that we routinely provide.

MatGen is synonymous with bespoke

MatGen is a computational contract research organization (CRO) and staff augmentation company specializing in flexible, tailored engagements. We collaborate with clients either on a per-project basis or by embedding our computational experts directly into client teams - full-time or part-time - to perform analyses, develop pipelines, and seamlessly integrate with existing workflows.

MatGen employs and connects an extensive network of expert data scientists, computational biologists and chemists, and software engineers, ensuring top-tier talent tailored specifically to your project needs.

Our approach is grounded in rigorous data modeling and computational excellence, yet fully adaptable to diverse client requirements. Below, we highlight project categories where we've delivered significant impact.

From conceptualization, through clinical trials, to market

Target identification and validation

GWAS and exome sequencing analysis
RNA-seq/transcriptomics profiling
Natural language processing for target discovery
Network and pathway mapping

Single-cell RNA analysis and clustering
Proteomics and metabolomics analysis
AI-powered medical image analysis
Multi-omics data integration

Structural modeling

Molecular dynamics simulations
AI-based structure prediction
Target-ligand docking analysis
Cryo-EM and NMR data processing

Macromolecule flexibility assessment
Structure-based druggability analysis
Protein and/or oligonucleotide interaction modeling
Custom visualization platforms

Hit generation

AI-driven molecule generation
Machine learning virtual screening
Structure-activity modeling
High-content screening analysis

Biologics design (including chemically modified)
Drug repurposing analytics
Side effect prediction
Hit-to-lead assessment

Lead optimization

Downstream effect modeling
ADME/T property prediction
Polypharmacology analysis
Structure-guided optimization

Peptide, protein, RNA/DNA structure optimization
Deep learning compound design
Drug resistance modeling
Molecular property prediction

Preclinical modeling & analysis

PK/PD modeling and simulation
Toxicity and immunogenicity prediction
Transcriptome profile evaluation
AI-based histopathology analysis

Multi-omics data integration
Drug combination modeling
Biomarker development

Clinical trials

Patient cohort identification
Data analysis, visualization, management
Biomarker-based stratification
Survival analysis modeling

Treatment response prediction
Medical imaging analysis
Multi-omics biomarker discovery
Real-world data integration

How to get started with MatGen

Analytical services via staff augmentation, as listed above, are our bread and butter. We also have a track record of excellence in developing custom software solutions for our clients, from simple de-Excel-ification of customer data to increase data safety, consistency, and reproducibility, to building advanced AI pipelines to ensure that you get the most out of your data. See here for concrete examples of what we have created for our clients.

CRO and custom software services are our foremost focus, so we have made sure that the or working with MatGen is as smooth as possible from the logistical perspective. Navigate here to learn how the engagement process with MatGen works.

Finally, book a meeting with us, or, for other ways to drop us a line, have a look at our Contact section.